Buscopan blocks the transmission of the neural stimuli at the intramural ganglia of the hollow abdominal organs, which are innervated by the parasympathetic nervous system. Absorption and distribution studies established that Buscopan compositum is concentrated in the walls of the hollow abdominal organs causing a spasmolysis. This accounts for the lack of systemic atropine-like side effects. It remains mainly in the enterohepatic circulation. Dipyrone has central analgesic activity plus a direct effect on the smooth muscle cells, lowering the excitability of the smooth muscle fibres. This latter effect together with dipyrones antiinflammatory action enhances the properties of Buscopan. Dipyrone is well tolerated parenterally.
Buscopan compositum is recommended in all conditions of severe pain involving spasm in the gastrointestinal, biliary and urogenital tracts. With intravenous administration pain often recedes before the injection is completed and pain relief is clearly apparent. The injection may be repeated after four hours if necessary. The duration of action is approximately six hours.
It brings about the relief of colic by abolishing the spasm and relieving the pain ensuring a rapid return to normal peristalsis and intestinal function.
Assists in the treatment of gastroenteritis.
Spasm of the gastrointestinal, biliary or urogenital tracts associated with severe pain. Buscopan compositum relieves both pain and smooth muscle spasm.
Spasmodic colic, scours, oesophageal obstruction, enteritis with diarrhoea.
Pain with enteritis and digestive disturbance, diarrhoea, oesophageal obstruction, postparturient relief of pain, functional tympanitis.
All forms of colic, gastroenteritis, diarrhoea.
Colic, gastroenteritis with diarrhoea, vomiting, spasm of the urogenital tract, pain associated with digestive disturbances, tenesmus, urinary calculi.
DIRECTIONS FOR USE
Horses – 20-30 mL intravenously
Cattle- 20-30 mL intravenously or intramuscularly
Dogs- 1-2.5 mL subcutaneously or intravenously
Hyoscine-N-Butylbromide 4 mg/mL Dipyrone 500 mg/mL
Buscopan compositum is a combination of the spasmolytic agent (Hyoscine-N-Butylbromide) and the analgesic dipyrone.